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Aurora Kinase B/C 抑制剂

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产品目录号: A11168


产品名 目录号 价格 数量
GSK1070916 5mg A11168-5
¥ 900.00
GSK1070916 10mg A11168-10
¥ 1,500.00
GSK1070916 50mg A11168-50
¥ 4,000.00
GSK1070916 100mg A11168-100
¥ 7,000.00
GSK1070916 10mM * 1mL in DMSO A11168-10mM-D
¥ 1,000.00



GSK1070916 is a potent Aurora B/C kinase inhibitor (with IC50 of 3.5 nM/6.5 nM) with broad antitumor activity in tissue culture cells and human tumor xenograft models.





顾客使用 Adooq 产品发表的高质量科研文献

Chemical Information

目录号 A11168
Mechanism of action Inhibitor
分子量 507.63
化学分子式 C30H33N7O
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 942918-07-2
Synonyms GSK-1070916
SMILES code CCN1C=C(C(=N1)C2=CC=C(C=C2)NC(=O)N(C)C)C3=C4C=C(NC4=NC=C3)C5=CC(=CC=C5)CN(C)C
化学名称 N'-[4-[4-[2-[3-[(Dimethylamino)methyl]phenyl]-1H-pyrrolo[2,3-b]pyridin-4-yl]-1-ethyl-1H-pyrazol-3-yl]phenyl]-N,N-dimethylurea



GSK1070916 is a potent Aurora B/C kinase inhibitor (with IC50 of 3.5 nM/6.5 nM) with broad antitumor activity in tissue culture cells and human tumor xenograft models.

Target Value
AuroraB-INCENPIC50: 3.5nM
AuroraC-INCENPIC50: 6.5nM
FLT1IC50: 42nM
Tie-2IC50: 59nM
SIKIC50: 70nM
FLT4IC50: 74nM
FGFR1IC50: 76nM
AuroraA-TPX2IC50: 1.1μM


Solubility (25°C) * In vitro DMSO 102 mg/mL (200.93 mM)
Water <1 mg/mL (<1 mM)
Ethanol 102 mg/mL (200.93 mM)
In vivo 2% Cremophor EL, 2% N,N-dimethylacetamide, pH 5.0 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.


Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.7 mL 98.5 mL 196.99mL
0.5 mM 3.94 mL 19.7 mL 39.4 mL
1 mM 1.97 mL 9.85 mL 19.7 mL
5 mM 0.39 mL 1.97 mL 3.94 mL

*The above data is based on the productmolecular weight 507.63. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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