GSK1120212 (JTP-74057, Trametinib)

Name: GSK1120212 (JTP-74057, Trametinib)
SKU: A11029
Price: 175 CNY
Rating: 5 (15 reviews)

目录号: A11029

MEK 抑制剂

15 篇发表文献

GSK1120212（JTP-74057）强烈抑制了MEK1和MEK2激酶的活性，而不是其他98种激酶的活性。

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Grouped product items
规格	价格	库存
5mg	¥175.00	现货
10mg	¥315.00	现货
50mg	¥385.00	现货
100mg	¥665.00	现货
200mg	¥945.00	现货
500mg	¥1,750.00	现货
*10mM 1mL in DMSO**	¥315.00	现货
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重要通知：仅供研究使用。我们不向患者销售。

Data Sheet

SDS

顾客使用 Adooq 产品发表的高质量科研文献

Adooq用户使用GSK1120212 (JTP-74057, Trametinib)发表的15篇文献

Song Han, .et al. , Neoplasia, 2025, Jan:59:101070 PMID: 39541736

Majid Momeny, .et al. , EMBO Mol Med, 2024, Jun 17 PMID: 38886591

Meenu Kesarwani, .et al. , Blood Adv, 2024, Jun 11;8(11):2765-2776 PMID: 38531054

Saeko Yoshioka, .et al. , Int J Tryptophan Res, 2022, Nov 30;15 PMID: 36467776

Tsung-Ming Chang, .et al. , Journal of Biomedical Science, 2022, 29:92

Nao Yamagishi, .et al. , Biol Pharm Bull, 2022, 45(10):1553-1558 PMID: 36184515

Hayato Mizuta, .et al. , Nat Commun, 2021, Feb 24;12(1):1261 PMID: 33627640

Keisuke Yanagida, .et al. , Dev Cell, 2020, 52 (6), 779-793 PMID: 32059774

Hamzehlou S, .et al. , Eur J Pharmacol, 2019, Nov 15;863:172705 PMID: 31574259

Kanemaru Y, .et al. , Acta Neuropathol Commun, 2019, Jul 25;7(1):119 PMID: 31345255

Chul Min Park, .et al. , Oncol Lett, 2018, Feb; 15(2): 1758-1762 PMID: 29434871

Sumi T, .et al. , Biochem Biophys Res Commun, 2018, Jun 18;501(1):253-258 PMID: 29727601

Toshiyuki Sumi, .et al. , Int J Oncol, 2018, Jul; 53(1): 33-46 PMID: 29658609

Fujita KI, .et al. , J Pharm Sci, 2017, Sep;106(9):2632-2641 PMID: 28479358

Yuki Kawasaki, .et al. , Sci Rep, 2016, 6: 31502 PMID: 27531070

生物活性

Discription

GSK1120212 (JTP-74057) strongly prevented the activities of MEK1 and MEK2 kinases rather than activities of other 98 kinases.

Targets

Target	Value

Cell Research

Cell Line	Type	Value	Description	References

产品信息

目录号	A11029
分子式	C26H23FIN5O4
分子量	615.4
CAS号	871700-17-3
SMILES	CC1=C2C(=C(N(C1=O)C)NC3=C(C=C(C=C3)I)F)C(=O)N(C(=O)N2C4=CC(=CC=C4)NC(=O)C)C5CC5
其他名称	GSK-1120212, GSK212, Trametinib
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

溶解性数据

In vitro (25°C)	DMSO	Warmed: 19 mg/mL (30.87 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	4% DMSO+corn oil	2 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	16.25 mL	81.25 mL	162.5 mL
0.5 mM	3.25 mL	16.25 mL	32.5 mL
1 mM	1.62 mL	8.12 mL	16.25 mL
5 mM	0.32 mL	1.62 mL	3.25 mL

Useful Calculator

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This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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