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GSK1838705A

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IGF-1R 抑制剂

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产品目录号: A11175

库存状态:中国现货中国现货

产品名 目录号 价格 数量
GSK1838705A 5mg A11175-5
¥ 900.00
GSK1838705A 10mg A11175-10
¥ 1,600.00
GSK1838705A 50mg A11175-50
¥ 6,200.00
GSK1838705A 100mg A11175-100
¥ 9,500.00
GSK1838705A 10mM * 1mL in DMSO A11175-10mM-D
¥ 1,550.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

GSK1838705A is a small-molecule kinase inhibitor that inhibits IGF-IR and the insulin receptor with IC50s of 2.0 and 1.6 nmol/L, respectively.

GSK1838705A

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顾客使用 Adooq 产品发表的高质量科研文献
Adooq 顾客使用 GSK1838705A 发表的文献 (1)
  • Watanabe S, .et al. Insulin augments serotonin-induced contraction via activation of the IR/PI3K/PDK1 pathway in the rat carotid artery, Pflugers Arch, 2016, Apr;468(4):667-77 PMID: 26577585

Chemical Information

目录号 A11175
Mechanism of action Inhibitor
分子量 532.57
化学分子式 C27H29FN8O3
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 1116235-97-2
Synonyms GSK-1838705A
SMILES code CNC(=O)C1=C(C=CC=C1F)NC2=NC(=NC3=C2C=CN3)NC4=C(C=C5CCN(C5=C4)C(=O)CN(C)C)OC
化学名称 2-(2-(1-(2-(dimethylamino)acetyl)-5-methoxyindolin-6-ylamino)-7H pyrrolo[2,3-d] pyrimidin-4-ylamino)-6-fluoro-N-methylbenzamide

生物活性

Description

GSK1838705A is a small-molecule kinase inhibitor that inhibits IGF-IR and the insulin receptor with IC50s of 2.0 and 1.6 nmol/L, respectively.

Targets
Target Value
ALKIC50: 0.5nM
Insulin ReceptorIC50: 1.6nM
IGF-1RIC50: 2nM
RSK1IC50: 1.6μM
JNK3IC50: 2μM
B-Raf(V600E)IC50: >2μM
JNK1IC50: 5μM
JAK3IC50: 5μM
JNK2IC50: 8μM
Akt1IC50: >10μM
Akt2IC50: >10μM
ALK5IC50: >10μM
AuroraAIC50: >10μM
AuroraBIC50: >10μM
CaMKK2IC50: >10μM
CDK2/CyclinAIC50: >10μM
EGFRIC50: >10μM
ErbB2IC50: >10μM
HGKIC50: >10μM
IKK3IC50: >10μM
PAK1IC50: >10μM
PCTAIRE1IC50: >10μM
PDK-1IC50: >10μM
PI3KαIC50: >10μM
PI3KβIC50: >10μM
PI3KδIC50: >10μM
PI3KγIC50: >10μM
PKCεIC50: >10μM
ROCK1IC50: >10μM
Src1IC50: >10μM
VEGFR2IC50: >10μM
YAK3IC50: >10μM
p70S6KIC50: >10μM
JAK2IC50: 13μM
JAK1IC50: >25μM
ASK1IC50: >25μM
ErbB4IC50: >25μM
GSK-3βIC50: >25μM
IKK1IC50: >25μM
IKK2IC50: >25μM
ITKIC50: >25μM
LCKIC50: >25μM
MAPKAPK2IC50: >25μM
p38αIC50: >25μM
SykIC50: >25μM
ZAP70IC50: >25μM

溶解性

Solubility (25°C) * In vitro DMSO 107 mg/mL (200.91 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 15% Captisol/citrate vehicle 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 18.78 mL 93.88 mL 187.77mL
0.5 mM 3.76 mL 18.78 mL 37.55 mL
1 mM 1.88 mL 9.39 mL 18.78 mL
5 mM 0.38 mL 1.88 mL 3.76 mL

*The above data is based on the productmolecular weight 532.57. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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