Trusted by 10,000+ Scientists since 2006
微信关注
申请试用装

GSK1904529A

促销

IGF-1R 抑制剂

0 Customer Reviews
产品目录号: A10440

库存状态:中国现货中国现货

产品名 目录号 价格 数量
GSK1904529A 5mg A10440-5
¥ 800.00
GSK1904529A 10mg A10440-10
¥ 1,380.00
GSK1904529A 25mg A10440-25
¥ 2,000.00
GSK1904529A 50mg A10440-50
¥ 3,480.00
GSK1904529A 10mM * 1mL in DMSO A10440-10mM-D
¥ 2,290.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

GSK1904529A selectively inhibits IGF-IR and IR with IC(50)s of 27 and 25 nmol/L, respectively.

GSK1904529A

双击上述图片即可查看完整大小

缩小
放大

更多视图

顾客使用 Adooq 产品发表的高质量科研文献

Chemical Information

目录号 A10440
Mechanism of action Inhibitor
分子量 852
化学分子式 C44H47F2N9O5S
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 1089283-49-7
Synonyms GSK-1904529A
SMILES code CCC1=CC(=C(C=C1N2CCC(CC2)N3CCN(CC3)S(=O)(=O)C)OC)NC4=NC=CC(=N4)C5=C(N=C6N5C=CC=C6)C7=CC(=C(C=C7)OC)C(=O)NC8=C(C=CC=C8F)F
化学名称 N-(2,6-Difluorophenyl)-5-[3-[2-[[5-ethyl-2-(methyloxy)-4-[4-[4-(methylsulfonyl)-1-piperazinyl]-1-piperidinyl]phenyl]amino]-4-pyrimidinyl]imidazo[1,2-a]pyridin-2-yl]-2-(methyloxy)benzamide

生物活性

Description
GSK1904529A selectively inhibits IGF-IR and IR with IC(50)s of 27 and 25 nmol/L, respectively.
Targets
Target Value
Insulin ReceptorIC50: 25nM
IGF-1RIC50: 27nM
B-Raf(V600E)IC50: >2μM
SykIC50: 3.2μM
VEGFR2IC50: 3.2μM
IKK3IC50: 3.2μM
AuroraBIC50: 4μM
FynIC50: 6.3μM
RSK1IC50: 6.3μM
LCKIC50: 8μM
AuroraAIC50: >8μM
p38αIC50: 10μM
PKCεIC50: 10μM
PKCθIC50: >10μM
ActRIIBIC50: >10μM
Akt1IC50: >10μM
Akt2IC50: >10μM
ALK5IC50: >10μM
CaMKK2IC50: >10μM
CDK2/CyclinAIC50: >10μM
EGFRIC50: >10μM
ErbB2IC50: >10μM
JNK1IC50: >10μM
JNK2IC50: >10μM
JNK3IC50: >10μM
p70S6KIC50: >10μM
PAK1IC50: >10μM
PCTAIRE1IC50: >10μM
PDK-1IC50: >10μM
PI3KαIC50: >10μM
PI3KβIC50: >10μM
PI3KδIC50: >10μM
PI3KγIC50: >10μM
ROCK1IC50: >10μM
SIK2IC50: >10μM
Src1IC50: >10μM
YAK3IC50: >10μM
IKK1IC50: 13μM
IKK2IC50: 13μM
JAK3IC50: 13μM
JAK2IC50: >16μM
ZAP70IC50: >20μM
ASK1IC50: >25μM
ErbB4IC50: >25μM
GSK-3βIC50: >25μM
ITKIC50: >25μM
MAPKAPK2IC50: >25μM

溶解性

Solubility (25°C)* In vitro DMSO 124 mg/mL (145.54 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 11.74 mL 58.69 mL 117.37mL
0.5 mM 2.35 mL 11.74 mL 23.47 mL
1 mM 1.17 mL 5.87 mL 11.74 mL
5 mM 0.23 mL 1.17 mL 2.35 mL

*The above data is based on the productmolecular weight 852. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Ordering online

To place an order online, simply browse to the product you are interested in and click on the 'Add to Cart' button. To complete this process, you will need to confirm the size and quantity of the products that you require.

To complete an order you will need to register using our simple online registration process. We do not share your contact details with any third parties.

When you are ready to check out simply enter your PO number to complete the ordering process. Please ensure that you send us a copy of your PO by fax or email afterwards.  We will then liaise with you or your purchasing department to confirm the order.

Found your products but not ready to order?

Why not use our WishList feature to store lists of products? This convenient feature allows you to manage lists, append notes to products and share lists with co-workers or colleagues.

Ordering offline

You can email or fax us your purchase order and we will place the order for you. You can also phone us to place the order.  Our contact details are:

We require the following information to process your order:
  • The catalog number for each product. 
  • Your email address or fax number. 
  • Your name and telephone number. 
  • Shipping address and billing address.
  • Purchase order numbers.

产品标签

使用空格分隔标签。使用单引号(')标注词组。

Similar product(s)


Keywords:购买 GSK1904529A | GSK1904529A 供应商 | 订购 GSK1904529A | GSK1904529A 价格 | GSK1904529A 生产商 | 订单 GSK1904529A | GSK1904529A 代理商 | 购买 1089283-49-7| 1089283-49-7 供应商 | 订购 1089283-49-7 | 1089283-49-7 价格 | 1089283-49-7 生产商 | 订单 1089283-49-7 | 1089283-49-7 代理商|buy GSK1904529A | GSK1904529A Supplier | purchase GSK1904529A | GSK1904529A cost | GSK1904529A manufacturer | order GSK1904529A | GSK1904529A distributor | buy 1089283-49-7| 1089283-49-7 Supplier | purchase 1089283-49-7 | 1089283-49-7 cost | 1089283-49-7 manufacturer | order 1089283-49-7 | 1089283-49-7 distributor