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GSK2126458 (Omipalisib)


mTOR/PI3K 抑制剂,

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产品目录号: A11035


产品名 目录号 价格 数量
GSK2126458 2mg A11035-2
¥ 800.00
GSK2126458 5mg A11035-5
¥ 1,200.00
GSK2126458 10mg A11035-10
¥ 1,600.00
GSK2126458 50mg A11035-50
¥ 4,200.00
GSK2126458 10mM * 1mL in DMSO A11035-10mM-D
¥ 1,300.00



GSK2126458 is a highly potent, orally bioavailable inhibitor of PI3Kα and mTOR with in vivo activity in both pharmacodynamic and tumor growth efficacy models.

GSK2126458 (Omipalisib)




顾客使用 Adooq 产品发表的高质量科研文献

Chemical Information

目录号 A11035
Mechanism of action Inhibitor
分子量 505.5
化学分子式 C25H17F2N5O3S
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 1086062-66-9
Synonyms GSK-2126458
SMILES code COC1=C(C=C(C=N1)C2=CC3=C(C=CN=C3C=C2)C4=CN=NC=C4)NS(=O)(=O)C5=C(C=C(C=C5)F)F
化学名称 2,4-Difluoro-N-{2-(methyloxy)-5-[4-(4-pyridazinyl)-6-quinolinyl]-3-pyridinyl}benzenesulfonamide


GSK2126458 is a highly potent, orally bioavailable inhibitor of PI3Kα and mTOR with in vivo activity in both pharmacodynamic and tumor growth efficacy models.
Target Value
p110αki: 0.019nM
p110δki: 0.024nM
p110γki: 0.06nM
p110βki: 0.13nM
mTORC1ki: 0.18nM
mTORC2ki: 0.3nM


Solubility (25°C) * In vitro DMSO 100 mg/mL (197.82 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 1% DMSO/30% polyethylene glycol/1% Tween 80 18 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.


Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.78 mL 98.91 mL 197.82mL
0.5 mM 3.96 mL 19.78 mL 39.56 mL
1 mM 1.98 mL 9.89 mL 19.78 mL
5 mM 0.4 mL 1.98 mL 3.96 mL

*The above data is based on the productmolecular weight 505.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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