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GSK256066是一种选择性PDE4B（与A-D型同等亲和力）抑制剂，IC50为3.2 pM，对PDE1/2/3/5/6的选择性> 380,000倍，对PDE4B与PDE7的选择性> 2500倍。
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 15.81 mL | 79.04 mL | 158.08 mL |
| 0.5 mM | 3.16 mL | 15.81 mL | 31.62 mL |
| 1 mM | 1.58 mL | 7.9 mL | 15.81 mL |
| 5 mM | 0.32 mL | 1.58 mL | 3.16 mL |
*The above data is based on the productmolecular weight 632.61. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A15097 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 632.61 |
| Formula | C29H27F3N4O7S |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 1415560-64-3 |
| Synonyms | GSK-256066, GSK 256066 |
| SMILES | CC1=C2C(=CC(=C1)S(=O)(=O)C3=CC=CC(=C3)C(=O)N(C)C)C(=C(C=N2)C(=O)N)NC4=CC(=CC=C4)OC.C(=O)(C(F)(F)F)O |
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