GSK256066
目录号: A11073
PDE 抑制剂
GSK256066 是一种具有极高亲和力和选择性的 PDE4 抑制剂，它对 PDE4 亚型 A-D 具有相同的亲和力，并且具有高 HARBS（High-Affinity Rolipram Binding Site）比率（>17）。
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生物活性
| Discription | GSK256066 is an exceptionally high affinity and selective inhibitor of PDE4 that inhibits PDE4 isoforms A-D with equal affinity and has a high HARBS (High-Affinity Rolipram Binding Site) ratio (>17). | ||
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产品信息
| 目录号 | A11073 |
|---|---|
| 分子式 | C27H26N4O5S |
| 分子量 | 518.6 |
| CAS号 | 801312-28-7 |
| SMILES | CC1=C2C(=CC(=C1)S(=O)(=O)C3=CC=CC(=C3)C(=O)N(C)C)C(=C(C=N2)C(=O)N)NC4=CC(=CC=C4)OC |
| 其他名称 | GSK-256066 |
| 储存条件 | Store lyophilized at -20ºC, keep desiccated. |
溶解性数据
| In vitro (25°C) | DMSO | 4 mg/mL (7.71 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
| In vivo | 30% propylene glycol, 5% Tween 80, 65% D5W | 28 mg/mL | |
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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Preparing Stock Solutions
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 19.28 mL | 96.41 mL | 192.83 mL |
| 0.5 mM | 3.86 mL | 19.28 mL | 38.57 mL |
| 1 mM | 1.93 mL | 9.64 mL | 19.28 mL |
| 5 mM | 0.39 mL | 1.93 mL | 3.86 mL |
Useful Calculator
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2
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| 购买 801312-28-7 | 801312-28-7 供应商 | 801312-28-7 花费 | 801312-28-7 生产商 | 订购 801312-28-7 | 801312-28-7 代理商