GSK2578215A

目录号: A12798

LRRK2 kinase 抑制剂

GSK2578215A

GSK2578215A Chemical Structure

CAS NO. 1285515-21-0

GSK2578215A是一种有效的富含亮氨酸的重复激酶2(LRRK2)抑制剂(LRRK2 [G2019S]突变体和野生型LRRK2的IC50值分别为8.9和10.1 nM)。

库存: 现货

规格 价格 数量
10 mg
¥ 600.00
25 mg
¥ 1,200.00
50 mg
¥ 2,300.00
100 mg
¥ 4,000.00
10mM * 1mL in DMSO
¥ 870.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

产品详情

GSK2578215A是一种有效的富含亮氨酸的重复激酶2(LRRK2)抑制剂(LRRK2 [G2019S]突变体和野生型LRRK2的IC50值分别为8.9和10.1 nM)。
靶点信息
LRRK2 (G2019S) LRRK2 (WT)
8.9 nM10.9 nM
In vitro DMSO Warmed: 73 mg/mL (182.76 mM)
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 25.04 mL 125.18 mL 250.36 mL
0.5 mM 5.01 mL 25.04 mL 50.07 mL
1 mM 2.5 mL 12.52 mL 25.04 mL
5 mM 0.5 mL 2.5 mL 5.01 mL

*The above data is based on the productmolecular weight 399.42. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A12798
作用机制 Inhibitor (抑制剂)
M. Wt 399.42
Formula C24H18FN3O2
Purity >99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No. 1285515-21-0
Synonyms GSK-2578215A, GSK 2578215A
SMILES C1=CC=C(C=C1)COC2=C(C=C(C=C2)C3=CC(=NC=C3)F)C(=O)NC4=CN=CC=C4

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