GSK2982772
目录号: A19380
RIP1 kinase 抑制剂
GSK2982772 是一种效力强大的、口服活性的、与ATP竞争的 RIP1激酶抑制剂，其 IC50 值分别为人类和猴子 RIP1 的16 nM和20 nM。
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生物活性
| Discription | GSK2982772 is a potent, orally active and ATP competitive RIP1 kinase inhibitor with IC50 values of 16 nM and 20 nM for human and monkey RIP1, respectively. | |||||
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| Cell Research |
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产品信息
| 目录号 | A19380 |
|---|---|
| 分子式 | C20H19N5O3 |
| 分子量 | 377.4 |
| CAS号 | 1622848-92-3 |
| SMILES | O=C(C1=NC(CC2=CC=CC=C2)=NN1)N[C@H]3COC4=CC=CC=C4N(C)C3=O |
| 其他名称 | GSK 2982772, GSK 2982772 |
| 储存条件 | Store lyophilized at -20ºC, keep desiccated. |
溶解性数据
| In vitro | DMSO | 66 mg/mL (174.87 mM) | |
| Water | Insoluble | ||
| Ethanol | 26 mg/mL (68.89 mM) | ||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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Preparing Stock Solutions
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 26.5 mL | 132.49 mL | 264.97 mL |
| 0.5 mM | 5.3 mL | 26.5 mL | 52.99 mL |
| 1 mM | 2.65 mL | 13.25 mL | 26.5 mL |
| 5 mM | 0.53 mL | 2.65 mL | 5.3 mL |
Useful Calculator
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2
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