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GSK3004774 is a potent, nonabsorbable agonist of CaSR, with an pEC50 of 7.3, 6.6 and 6.5 for human, mouse and rat CaSR, respectively. GSK3004774 shows an EC50 of 50 nM for human CaSR.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 18.91 mL | 94.57 mL | 189.15 mL |
| 0.5 mM | 3.78 mL | 18.91 mL | 37.83 mL |
| 1 mM | 1.89 mL | 9.46 mL | 18.91 mL |
| 5 mM | 0.38 mL | 1.89 mL | 3.78 mL |
*The above data is based on the productmolecular weight 528.69. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A19779 |
|---|---|
| M. Wt | 528.69 |
| Formula | C32H40N4O3 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 2138814-32-9 |
| Synonyms | GSK 3004774, GSK-3004774 |
| SMILES | O=C(NCCCN1CCC(C(O)=O)CC1)C(C=C2)=CC=C2N(CC3)C[C@H]3N[C@H](C)C4=CC=CC5=C4C=CC=C5 |
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