GSK343

目录号: A13114

EZH2 抑制剂

GSK343

GSK343 Chemical Structure

CAS NO. 1346704-33-3

GSK343是有效的组蛋白H3-赖氨酸27(H3K27)甲基转移酶EZH2抑制剂(IC = 4 nM)。对除EZH1以外的其他HMT的选择性是1000倍(选择性是60倍)。GSK343抑制HCC1806细胞中的H3K27甲基化,IC小于200nM(通过免疫荧光测量)。

库存: 现货

规格 价格 数量
5 mg
¥ 500.00
10 mg
¥ 800.00
25 mg
¥ 1,500.00
50 mg
¥ 2,500.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

产品详情

GSK343是有效的组蛋白H3-赖氨酸27(H3K27)甲基转移酶EZH2抑制剂(IC = 4 nM)。对除EZH1以外的其他HMT的选择性是1000倍(选择性是60倍)。GSK343抑制HCC1806细胞中的H3K27甲基化,IC小于200nM(通过免疫荧光测量)。
靶点信息
EZH2 (Cell-free assay) EZH1 (Cell-free assay)
4 nM240 nM
In vitro DMSO Warmed: 1 mg/mL (1.84 mM)
Water Insoluble
Ethanol 3 mg/mL (5.54 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 18.46 mL 92.3 mL 184.61 mL
0.5 mM 3.69 mL 18.46 mL 36.92 mL
1 mM 1.85 mL 9.23 mL 18.46 mL
5 mM 0.37 mL 1.85 mL 3.69 mL

*The above data is based on the productmolecular weight 541.69. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A13114
作用机制 Inhibitor (抑制剂)
M. Wt 541.69
Formula C31H39N7O2
Purity >99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No. 1346704-33-3
Synonyms GSK-343, GSK 343
SMILES CCCC1=C(C(=O)NC(=C1)C)CNC(=O)C2=C3C=NN(C3=CC(=C2)C4=CC(=NC=C4)N5CCN(CC5)C)C(C)C

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