GSK481

目录号: A12615

RIP1 inhibitor

GSK481 Chemical Structure

CAS NO. 1622849-58-4

GSK481 is a novel benzoxazepinone (BOAz) series of RIP1 inhibitors. Receptor Interacting Protein Kinase 1 (RIP1) has been implicated as a key contributor to inflammation through the regulation of programmed necrosis. Inhibition of this kinase has been shown to hinder cell necrotic death, thereby establishing RIP1 as a viable target for the potential treatment of multiple inflammatory diseases.

库存: 现货

规格 价格 数量
5 mg
¥ 1,000.00
10 mg
¥ 1,500.00
25 mg
¥ 2,800.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

产品详情

GSK481 is a novel benzoxazepinone (BOAz) series of RIP1 inhibitors. Receptor Interacting Protein Kinase 1 (RIP1) has been implicated as a key contributor to inflammation through the regulation of programmed necrosis. Inhibition of this kinase has been shown to hinder cell necrotic death, thereby establishing RIP1 as a viable target for the potential treatment of multiple inflammatory diseases.
靶点信息
RIP1
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 26.5 mL 132.49 mL 264.98 mL
0.5 mM 5.3 mL 26.5 mL 53 mL
1 mM 2.65 mL 13.25 mL 26.5 mL
5 mM 0.53 mL 2.65 mL 5.3 mL

*The above data is based on the productmolecular weight 377.39. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A12615
MECHANISM OF ACTION Inhibitor
M. Wt 377.39
Formula C21H19N3O4
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1622849-58-4
Synonyms GSK 481, GSK-481
SMILES O=C(C1=NOC(CC2=CC=CC=C2)=C1)N[C@H]3COC4=CC=CC=C4N(C)C3=O

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