GSK547
目录号: A19073
RIP1 抑制剂
GSK547（GSK-547）是一种高度选择性且有效的受体相互作用丝氨酸/苏氨酸蛋白激酶1（RIP1）抑制剂，能够抑制胰腺癌中巨噬细胞介导的适应性免疫耐受。
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生物活性
| Discription | GSK547 (GSK-547) is a highly selective and potent inhibitor of receptor-interacting serine/threonine protein kinase 1 (RIP1), inhibits macrophage-mediated adaptive immune tolerance in pancreatic cancer. | |||||
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| Cell Research |
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产品信息
| 目录号 | A19073 |
|---|---|
| 分子式 | C20H18F2N6O |
| 分子量 | 396.39 |
| CAS号 | 2226735-55-1 |
| SMILES | N#CC1=NC=NC(N2CCC(C(N3N=CC[C@H]3C4=CC(F)=CC(F)=C4)=O)CC2)=C1 |
| 其他名称 | GSK-547, GSK547 |
| 储存条件 | Store lyophilized at -20ºC, keep desiccated. |
溶解性数据
| In vitro | DMSO | 26 mg/mL (65.59 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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Preparing Stock Solutions
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 25.23 mL | 126.14 mL | 252.28 mL |
| 0.5 mM | 5.05 mL | 25.23 mL | 50.46 mL |
| 1 mM | 2.52 mL | 12.61 mL | 25.23 mL |
| 5 mM | 0.5 mL | 2.52 mL | 5.05 mL |
Useful Calculator
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2
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