GSK690693

目录号: A11030

AKT inhibitor

GSK690693

GSK690693 Chemical Structure

CAS NO. 937174-76-0

GSK690693 is a novel ATP-competitive, low-nanomolar pan-Akt kinase inhibitor (IC50 values are 2, 13 and 9 nM of Akt1, 2 and 3 respectively).

库存: 现货

规格 价格 数量
10 mg
¥ 1,200.00
25 mg
¥ 2,200.00
50 mg
¥ 3,600.00
100 mg
¥ 6,000.00
10mM * 1mL in DMSO
¥ 750.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

详情

GSK690693 is a novel ATP-competitive, low-nanomolar pan-Akt kinase inhibitor (IC50 values are 2, 13 and 9 nM of Akt1, 2 and 3 respectively).
Targets
Target Value
Akt1IC50: 2nM
PKCηIC50: 2nM
PKCθIC50: 2nM
PrkXIC50: 5nM
Akt3IC50: 9nM
Akt2IC50: 13nM
PKCδIC50: 14nM
PKCβIC50: 19nM
PKCεIC50: 21nM
PKAIC50: 24nM
PKG1βIC50: 33nM
In vitro (25°C) DMSO 39 mg/mL (91.66 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 15% Captisol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 23.5 mL 117.51 mL 235.02 mL
0.5 mM 4.7 mL 23.5 mL 47 mL
1 mM 2.35 mL 11.75 mL 23.5 mL
5 mM 0.47 mL 2.35 mL 4.7 mL

*The above data is based on the productmolecular weight 425.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Technical Details

目录号 A11030
MECHANISM OF ACTION Inhibitor
M. Wt 425.5
Formula C21H27N7O3
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 937174-76-0
Synonyms GSK-690693
SMILES CCN1C2=C(C(=NC=C2OC[C@H]3CCCNC3)C#CC(C)(C)O)N=C1C4=NON=C4N

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