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AKT 抑制剂

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产品目录号: A11030


产品名 目录号 价格 数量
GSK690693 10mg A11030-10
¥ 1,200.00
GSK690693 25mg A11030-25
¥ 2,200.00
GSK690693 50mg A11030-50
¥ 3,600.00
GSK690693 100mg A11030-100
¥ 6,000.00
GSK690693 10mM * 1mL in DMSO A11030-10mM-D
¥ 750.00



GSK690693 is a novel ATP-competitive, low-nanomolar pan-Akt kinase inhibitor (IC50 values are 2, 13 and 9 nM of Akt1, 2 and 3 respectively).





顾客使用 Adooq 产品发表的高质量科研文献
Adooq 顾客使用 GSK690693 发表的文献 (1)
  • Khan MI, .et al. Thalidomide attenuates development of morphine dependence in mice by inhibiting PI3K/Akt and nitric oxide signaling pathways, Prog Neuropsychopharmacol Biol Psychiatry, 2018, Mar 2;82:39-48 PMID: 9223784

Chemical Information

目录号 A11030
Mechanism of action Inhibitor
分子量 425.5
化学分子式 C21H27N7O3
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 937174-76-0
Synonyms GSK-690693
化学名称 4-[2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-[(3S)-3-piperidinylmethoxy)-1H-imidazo[4,5-c]pyridin-4-yl]-2-methyl-3-butyn-2-ol


GSK690693 is a novel ATP-competitive, low-nanomolar pan-Akt kinase inhibitor (IC50 values are 2, 13 and 9 nM of Akt1, 2 and 3 respectively).
Target Value
Akt1IC50: 2nM
PKCηIC50: 2nM
PKCθIC50: 2nM
PrkXIC50: 5nM
Akt3IC50: 9nM
Akt2IC50: 13nM
PKCδIC50: 14nM
PKCβIC50: 19nM
PKCεIC50: 21nM
PKAIC50: 24nM
PKG1βIC50: 33nM


Solubility (25°C) * In vitro DMSO 39 mg/mL (91.66 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 15% Captisol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.


Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 23.5 mL 117.51 mL 235.02mL
0.5 mM 4.7 mL 23.5 mL 47 mL
1 mM 2.35 mL 11.75 mL 23.5 mL
5 mM 0.47 mL 2.35 mL 4.7 mL

*The above data is based on the productmolecular weight 425.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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