GSK963
目录号: A18346
RIP1 kinase 抑制剂
GSK963 是一种手性的、高效且选择性的 RIP1激酶 抑制剂，其 IC50 为 29 nM。GSK963 在体外的小鼠和人类细胞中是一种选择性且强效的 坏死性凋亡 抑制剂。
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生物活性
| Discription | GSK963 is a chiral, highly potent and selective inhibitor of RIP1 kinase, with an IC50 of 29 nM. GSK963 is a selective and potent inhibitor of necroptosis in murine and human cells in vitro. | |||||
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| Cell Research |
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产品信息
| 目录号 | A18346 |
|---|---|
| 分子式 | C14H18N2O |
| 分子量 | 230.311 |
| CAS号 | 2049868-46-2 |
| SMILES | CC(C)(C)C(N1N=CC[C@H]1C2=CC=CC=C2)=O |
| 其他名称 | GSK 963, GSK-963 |
| 储存条件 | Store lyophilized at -20ºC, keep desiccated. |
溶解性数据
| In vitro | DMSO | 41 mg/mL (178.02 mM) | |
| Water | Insoluble | ||
| Ethanol | 41 mg/mL (178.02 mM) | ||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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Preparing Stock Solutions
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 43.42 mL | 217.1 mL | 434.2 mL |
| 0.5 mM | 8.68 mL | 43.42 mL | 86.84 mL |
| 1 mM | 4.34 mL | 21.71 mL | 43.42 mL |
| 5 mM | 0.87 mL | 4.34 mL | 8.68 mL |
Useful Calculator
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2
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