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GW 441756

TrkA 抑制剂

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产品目录号: A16238


产品名 目录号 价格 数量
GW 441756 10mg A16238-10
¥ 800.00
GW 441756 50mg A16238-50
¥ 2,800.00



GW 441756 is a specific Tropomyosin-related kinase A (TrkA) inhibitor with an IC50 value of 2 nM; little activity to c-Raf1 and CDK2.

GW 441756




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Chemical Information

目录号 A16238
Mechanism of action Inhibitor
分子量 275.31
化学分子式 C17H13N3O
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 504433-23-2
Synonyms GW-441756, GW441756
SMILES code O=C1/C(C2=NC=CC=C2N1)=C\C3=CN(C)C4=C3C=CC=C4
化学名称 1,3-dihydro-3-[(1-methyl-1H-indol-3-yl)methylene]-2H-pyrrolo[3,2-b]pyridin-2-one


GW 441756 is a specific Tropomyosin-related kinase A (TrkA) inhibitor with an IC50 value of 2 nM; little activity to c-Raf1 and CDK2.
TrkA CDK2 C-Raf-1
2 nM>7 μM>12 μM


Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 36.32 mL 181.61 mL 363.23mL
0.5 mM 7.26 mL 36.32 mL 72.65 mL
1 mM 3.63 mL 18.16 mL 36.32 mL
5 mM 0.73 mL 3.63 mL 7.26 mL

*The above data is based on the productmolecular weight 275.31. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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