产品详情

生物活性

GW 9662是一种选择性PPARγ拮抗剂（PPARγ，PPARα和PPARδ的IC50值分别为3.3、32和2000 nM）。

靶点信息

PPARγ (Cell-free assay)	PPARα (Cell-free assay)	PPARδ (Cell-free assay)
3.3 nM	32 nM	2 μM

溶解度 *

In vitro (25°C)	DMSO	48 mg/mL (173.48 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	5% DMSO+corn oil	8 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	36.14 mL	180.71 mL	361.43 mL
0.5 mM	7.23 mL	36.14 mL	72.29 mL
1 mM	3.61 mL	18.07 mL	36.14 mL
5 mM	0.72 mL	3.61 mL	7.23 mL

*The above data is based on the productmolecular weight 276.68. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A11984
作用机制	Antagonist (拮抗剂)
M. Wt	276.68
Formula	C13H9N2O3Cl
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	22978-25-2
Synonyms	GW9662, GW-9662
SMILES	C1=CC=C(C=C1)NC(=O)C2=C(C=CC(=C2)[N+](=O)[O-])Cl