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GW788388

促销

TGF-beta/Smad 抑制剂

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产品目录号: A11083

库存状态:中国现货中国现货

产品名 目录号 价格 数量
GW788388 5mg A11083-5
¥ 380.00
GW788388 10mg A11083-10
¥ 600.00
GW788388 50mg A11083-50
¥ 2,000.00
GW788388 100mg A11083-100
¥ 3,600.00
GW788388 10mM * 1mL in DMSO A11083-10mM-D
¥ 910.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

GW788388 is a potent, orally active and selective inhibitor of transforming growth factor beta receptor I (TGF-βR1) (activin receptor-like kinase 5, ALK5).

GW788388

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Chemical Information

目录号 A11083
Mechanism of action Inhibitor
分子量 425.5
化学分子式 C25H23N5O2
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 452342-67-5
Synonyms GW-788388
SMILES code C1COCCC1NC(=O)C2=CC=C(C=C2)C3=NC=CC(=C3)C4=C(NN=C4)C5=CC=CC=N5
化学名称 4-[4-[3-(2-Pyridinyl)-1H-pyrazol-4-yl]-2-pyridinyl]-N-(tetrahydro-2H-pyran-4-yl)-benzamide

生物活性

Description
GW788388 is a potent, orally active and selective inhibitor of transforming growth factor beta receptor I (TGF-βR1) (activin receptor-like kinase 5, ALK5).
Targets
ALK5 (Cell-free assay)
18 nM

溶解性

Solubility (25°C) * In vitro DMSO 15 mg/mL (35.25 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 23.5 mL 117.51 mL 235.02mL
0.5 mM 4.7 mL 23.5 mL 47 mL
1 mM 2.35 mL 11.75 mL 23.5 mL
5 mM 0.47 mL 2.35 mL 4.7 mL

*The above data is based on the productmolecular weight 425.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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