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GZD824 Dimesylate

Bcr-Abl 抑制剂

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产品目录号: A15849

库存状态:中国现货中国现货

产品名 目录号 价格 数量
GZD824 5mg A15849-5
¥ 900.00
GZD824 10mg A15849-10
¥ 1,500.00
GZD824 25mg A15849-25
¥ 2,800.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

GZD824 is a novel orally bioavailable Bcr-Abl inhibitor for Bcr-Abl(WT) and Bcr-Abl(T315I) with IC50 of 0.34 nM and 0.68 nM, respectively.

GZD824 Dimesylate

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Chemical Information

目录号 A15849
Mechanism of action Inhibitor
分子量 724.77
化学分子式 C29H27F3N6O.2CH4O3S
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 1421783-64-3
Synonyms GZD-824 Dimesylate
SMILES code CC1=CC=C(C(NC2=CC=C(CN3CCN(C)CC3)C(C(F)(F)F)=C2)=O)C=C1C#CC4=CN=C5C(C=NN5)=C4.CS(=O)(O)=O.CS(=O)(O)=O
化学名称 3-((1H-pyrazolo[3,4-b]pyridin-5-yl)ethynyl)-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide dimethanesulfonate

生物活性

Description
GZD824 is a novel orally bioavailable Bcr-Abl inhibitor for Bcr-Abl(WT) and Bcr-Abl(T315I) with IC50 of 0.34 nM and 0.68 nM, respectively.
Targets
Target Value
Abl(Q252H)IC50: 0.15nM
Abl(E255K)IC50: 0.27nM
Abl(M351T)IC50: 0.29nM
AblIC50: 0.34nM
Abl(H396P)IC50: 0.35nM
Abl(Y253F)IC50: 0.35nM
Abl(T315I)IC50: 0.68nM
Abl(G250E)IC50: 0.71nM

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 13.8 mL 68.99 mL 137.97mL
0.5 mM 2.76 mL 13.8 mL 27.59 mL
1 mM 1.38 mL 6.9 mL 13.8 mL
5 mM 0.28 mL 1.38 mL 2.76 mL

*The above data is based on the productmolecular weight 724.77. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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