HDM201
目录号: A16834
MDM2 抑制剂
HDM201 是一种新型、高效且选择性的 p53-Mdm2 交互作用抑制剂，其对 Mdm2 的亲和常数在皮摩尔范围内，与 Mdm4 的选择性比率超过 10000 倍。
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生物活性
| Discription | HDM201 is a novel, highly potent and selective inhibitor of the p53-Mdm2 interaction with affinity constant for Mdm2 in the picomolar range and a selectivity ratio greater than 10000-fold vs Mdm4. |
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产品信息
| 目录号 | A16834 |
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| 分子式 | C26H24Cl2N6O4 |
| 分子量 | 555.41 |
| CAS号 | 1448867-41-1 |
| SMILES | O=C1N(C2=CC(Cl)=CN(C)C2=O)[C@@H](C3=CC=C(Cl)C=C3)C4=C1N=C(C5=CN=C(OC)N=C5OC)N4C(C)C |
| 其他名称 | NVP-HDM201, HDM 201, HDM-201 |
| 储存条件 | Store lyophilized at -20ºC, keep desiccated. |
溶解性数据
| In vitro | DMSO | 98 mg/mL (176.44 mM) | |
| Water | Insoluble | ||
| Ethanol | 3 mg/mL (5.4 mM) | ||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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Preparing Stock Solutions
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 18 mL | 90.02 mL | 180.05 mL |
| 0.5 mM | 3.6 mL | 18 mL | 36.01 mL |
| 1 mM | 1.8 mL | 9 mL | 18 mL |
| 5 mM | 0.36 mL | 1.8 mL | 3.6 mL |
Useful Calculator
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2
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| 购买 1448867-41-1 | 1448867-41-1 供应商 | 1448867-41-1 花费 | 1448867-41-1 生产商 | 订购 1448867-41-1 | 1448867-41-1 代理商