HFB-200301 is a monoclonal IgG1 antibody specifically designed to target tumor necrosis factor receptor 2 (TNFR2). This antibody facilitates the activation of TNFR2, which in turn initiates the classical NF-??B signaling pathway, involving the activation of RelA and cRel-containing NF-??B dimers. This activation impacts cellular metabolism and gene expression in response to soluble TNF (sTNF). HFB-200301 holds significant potential for advancing research in cancer biology, particularly in studies exploring the molecular mechanisms of TNFR2 in tumor progression and immune responses.
HFB-200301 is a monoclonal IgG1 antibody specifically designed to target tumor necrosis factor receptor 2 (TNFR2). This antibody facilitates the activation of TNFR2, which in turn initiates the classical NF-??B signaling pathway, involving the activation of RelA and cRel-containing NF-??B dimers. This activation impacts cellular metabolism and gene expression in response to soluble TNF (sTNF). HFB-200301 holds significant potential for advancing research in cancer biology, particularly in studies exploring the molecular mechanisms of TNFR2 in tumor progression and immune responses.
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