HG-9-91-01 | SIK inhibitor | 美国进口 | HG-9-91-01 供应商 AdooQ®

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生物活性

HG-9-91-01 is a potent and highly selective salt-inducible kinase (SIK) inhibitor with IC50s of 0.92 nM, 6.6 nM and 9.6 nM for SIK1, SIK2 and SIK3 respectively.

溶解度 *

In vitro	DMSO	91 mg/mL (160.3 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	17.62 mL	88.08 mL	176.16 mL
0.5 mM	3.52 mL	17.62 mL	35.23 mL
1 mM	1.76 mL	8.81 mL	17.62 mL
5 mM	0.35 mL	1.76 mL	3.52 mL

*The above data is based on the productmolecular weight 567.68. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A21004
作用机制	Inhibitor (抑制剂)
M. Wt	567.68
Formula	C32H37N7O3
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	1456858-58-4
SMILES	CC1=CC=CC(C)=C1NC(N(C2=NC=NC(NC3=CC=C(N4CCN(C)CC4)C=C3)=C2)C5=CC=C(OC)C=C5OC)=O

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