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Histatin-3 TFA

目录号: A23193
Histatin-3 TFA,一种含有32个氨基酸的肽,具有强大的抗菌特性。Histatin-3 TFA 作为前体蛋白转化酶1(PC1)的底物,主要在单个Arg25残基(HRGYR decrease SN)的羧基末端被这种内蛋白酶切割。Histatin-3 TFA 是一种中等效力的、可逆的、竞争性抑制剂,能够抑制furin介导的五肽pGlu-Arg-Thr-Lys-Arg-MCA荧光底物的切割,估计的抑制常数Ki为1.98 μM。
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1mg
¥280.00
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5mg
¥875.00
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10mg
¥1,470.00
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生物活性
Discription Histatin-3 TFA, a 32 amino acid peptide, possesses powerful antimicrobial properties. Histatin-3 TFA behaves as a substrate for proprotein convertase 1 (PC1), being cleaved by this endoprotease primarily at a site carboxy terminal to the single Arg25 residue (HRGYR decrease SN). Histatin-3 TFA is a moderately potent, reversible and competitive inhibitor of the furin-mediated cleavage of the pentapeptide pGlu-Arg-Thr-Lys-Arg-MCA fluorogenic substrate, with an estimated inhibition constant Ki of 1.98 μM.
产品信息
目录号 A23193
分子式 C178H258N64O48.xC2HF3O2
分子量 4062.35 (free acid)
CAS号 112844-49-2
Sequence Asp-Ser-His-Ala-Lys-Arg-His-His-Gly-Tyr-Lys-Arg-Lys-Phe-His-Glu-Lys-His-His-Ser-His-Arg-Gly-Tyr-Arg-Ser-Asn-Tyr-Leu-Tyr-Asp-Asn
Sequence shortening DSHAKRHHGYKRKFHEKHHSHRGYRSNYLYDN
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