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HPOB

促销

HDAC6 抑制剂

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产品目录号: A14197

库存状态:中国现货中国现货

产品名 目录号 价格 数量
HPOB 10mg A14197-10
¥ 600.00
HPOB 25mg A14197-25
¥ 1,200.00
HPOB 50mg A14197-50
¥ 2,000.00
HPOB 10mM * 1mL in DMSO A14197-10mM-D
¥ 550.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

HPOB is a potent inhibitor of histone deacetylase 6 (HDAC6; IC50 = 56 nM).

HPOB

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Chemical Information

目录号 A14197
Mechanism of action Inhibitor
分子量 314.3
化学分子式 C17H18N2O4
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 1429651-50-2
Synonyms 0
SMILES code C1=CC=C(C=C1)N(CCO)C(=O)CC2=CC=C(C=C2)C(=O)NO
化学名称 4-[(hydroxyamino)carbonyl]-N-(2-hydroxyethyl)-N-phenyl-benzeneacetamide

生物活性

Description
HPOB is a potent inhibitor of histone deacetylase 6 (HDAC6; IC50 = 56 nM).
Targets
Target Value
HDAC6IC50: 56nM
HDAC3IC50: 1.7μM
HDAC8IC50: 2.8μM
HDAC1IC50: 2.9μM
HDAC10IC50: 3.0μM
HDAC2IC50: 4.4μM
HDAC4IC50: >10μM
HDAC5IC50: >10μM
HDAC7IC50: >10μM
HDAC9IC50: >10μM
HDAC11IC50: >10μM

溶解性

Solubility (25°C)* In vitro DMSO 62 mg/mL (197.23 mM)
Water <1 mg/mL (<1 mM)
Ethanol 38 mg/mL heating (120.88 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 31.82 mL 159.08 mL 318.17mL
0.5 mM 6.36 mL 31.82 mL 63.63 mL
1 mM 3.18 mL 15.91 mL 31.82 mL
5 mM 0.64 mL 3.18 mL 6.36 mL

*The above data is based on the productmolecular weight 314.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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