Ianalumab (FUT8-KO) is an anti-BAFF-R monoclonal antibody, produced in Chinese Hamster Ovary (CHO) cells with a targeted knockout of the fucosyltransferase 8 gene (FUT8). The absence of fucose on this antibody significantly enhances its Antibody-Dependent Cellular Cytotoxicity (ADCC) capabilities. This antibody effectively blocks the interaction between B-cell Activating Factor (BAFF) and its receptor BAFF-R, thereby inhibiting the BAFF-mediated apoptotic protection. This makes Ianalumab (FUT8-KO) a valuable tool for research into BAFF-R related signaling pathways and potential therapeutic interventions in autoimmune diseases and malignancies where BAFF and BAFF-R interactions play a critical role.
Ianalumab (FUT8-KO) is an anti-BAFF-R monoclonal antibody, produced in Chinese Hamster Ovary (CHO) cells with a targeted knockout of the fucosyltransferase 8 gene (FUT8). The absence of fucose on this antibody significantly enhances its Antibody-Dependent Cellular Cytotoxicity (ADCC) capabilities. This antibody effectively blocks the interaction between B-cell Activating Factor (BAFF) and its receptor BAFF-R, thereby inhibiting the BAFF-mediated apoptotic protection. This makes Ianalumab (FUT8-KO) a valuable tool for research into BAFF-R related signaling pathways and potential therapeutic interventions in autoimmune diseases and malignancies where BAFF and BAFF-R interactions play a critical role.
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