Ianalumab (VAY-736) is a humanized, decarboxylated monoclonal antibody that specifically targets BAFF-R (B-cell activating factor receptor). This antibody effectively blocks the interaction between BAFF (B-cell activating factor) and its receptor BAFF-R, thereby inhibiting the BAFF-mediated protection from apoptosis. Additionally, Ianalumab promotes antibody-dependent cellular cytotoxicity (ADCC) through the activation of effector cells mediated by the immune receptor tyrosine-based activation motif (ITAM). This dual mechanism of action makes Ianalumab a valuable tool for research into B-cell regulation and autoimmune disease therapies.
Ianalumab (VAY-736) is a humanized, decarboxylated monoclonal antibody that specifically targets BAFF-R (B-cell activating factor receptor). This antibody effectively blocks the interaction between BAFF (B-cell activating factor) and its receptor BAFF-R, thereby inhibiting the BAFF-mediated protection from apoptosis. Additionally, Ianalumab promotes antibody-dependent cellular cytotoxicity (ADCC) through the activation of effector cells mediated by the immune receptor tyrosine-based activation motif (ITAM). This dual mechanism of action makes Ianalumab a valuable tool for research into B-cell regulation and autoimmune disease therapies.
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