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Ibuprofen (Advil)

促销

COX-1 抑制剂

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产品目录号: A10461

库存状态:中国现货中国现货

产品名 目录号 价格 数量
Ibuprofen 200mg A10461-200
¥ 400.00
Ibuprofen 500mg A10461-500
¥ 950.00
Ibuprofen (Advil) 10mM * 1mL in DMSO A10461-10mM-D
¥ 590.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) targeting COX-1 with an IC50 of 13 μM.

Ibuprofen (Advil)

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顾客使用 Adooq 产品发表的高质量科研文献
Adooq 顾客使用 Ibuprofen (Advil) 发表的文献 (2)
  • Azuma T, .et al. Distribution of six anticancer drugs and a variety of other pharmaceuticals, and their sorption onto sediments, in an urban Japanese river, Environ Sci Pollut Res Int, 2017, Aug;24(23):19021-19030 PMID: 28660504
  • Azuma T, .et al. Detection of pharmaceuticals and phytochemicals together with their metabolites in hospital effluents in Japan, and their contribution to sewage treatment plant influents, Sci Total Environ, 2016, Apr 1;548-549:189-197 PMID: 26802347

Chemical Information

目录号 A10461
Mechanism of action Inhibitor
分子量 206.3
化学分子式 C13H18O2
Solubility
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 15687-27-1
Synonyms Genpril, Brufen, Nurofen, Motrin, Ibren, Ibuprohm
SMILES code CC(C)CC1=CC=C(C=C1)C(C)C(=O)O
化学名称 (RS)-2-(4-(2-methylpropyl)phenyl)propanoic acid

生物活性

Description
Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) targeting COX-1 with an IC50 of 13 μM.
Targets
COX-1 COX-2
13 μM370 μM

溶解性

Solubility (25°C) * In vitro DMSO 41 mg/mL (198.75 mM)
Water <1 mg/mL (<1 mM)
Ethanol 41 mg/mL (198.75 mM)
In vivo 1% DMSO/30% polyethylene glycol/1% Tween 80 20 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 48.47 mL 242.37 mL 484.73mL
0.5 mM 9.69 mL 48.47 mL 96.95 mL
1 mM 4.85 mL 24.24 mL 48.47 mL
5 mM 0.97 mL 4.85 mL 9.69 mL

*The above data is based on the productmolecular weight 206.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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