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ICG-001

促销

Wnt/beta-catenin 抑制剂

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产品目录号: A11039

库存状态:中国现货中国现货

产品名 目录号 价格 数量
ICG-001 5mg A11039-5
¥ 600.00
ICG-001 10mg A11039-10
¥ 1,000.00
ICG-001 25mg A11039-25
¥ 2,400.00
ICG-001 100mg A11039-100
¥ 5,500.00
ICG-001 10mM * 1mL in DMSO A11039-10mM-D
¥ 1,250.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

ICG-001 is a specific inhibitor of Wnt/β-catenin signaling pathway that inhibits β-catenin/cyclic AMP response element-binding (CREB) protein transcription (IC50=3 microM) .

ICG-001

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顾客使用 Adooq 产品发表的高质量科研文献
Adooq 顾客使用 ICG-001 发表的文献 (2)
  • Yamaoka R, .et al. CD90 expression in human intrahepatic cholangiocarcinoma is associated with lymph node metastasis and poor prognosis, J Surg Oncol, 2018, Sep;118(4):664-674 PMID: 30196535
  • Aida Y, .et al. Wnt3a promotes differentiation of human bone marrow-derived mesenchymal stem cells into cementoblast-like cells, In Vitro Cell Dev Biol Anim, 2018, Jun;54(6):468-476 PMID: 29785536

Chemical Information

目录号 A11039
Mechanism of action Inhibitor
分子量 548.6
化学分子式 C33H32N4O4
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 780757-88-2
Synonyms ICG001
SMILES code C1CN([C@H]2CN(C(=O)[C@@H](N2C1=O)CC3=CC=C(C=C3)O)CC4=CC=CC5=CC=CC=C54)C(=O)NCC6=CC=CC=C6
化学名称 (6S,9aS)-Hexahydro-6-[(4-hydroxyphenyl)methyl]-8-(1-naphthalenylmethyl)-4,7-dioxo-N-(phenylmethyl)-2H-pyrazino[1,2-a]pyrimidine-1(6H)-carboxamide

生物活性

Description
ICG-001 is a specific inhibitor of Wnt/β-catenin signaling pathway that inhibits β-catenin/cyclic AMP response element-binding (CREB) protein transcription (IC50=3 microM) .
Targets
CBP (Cell-free assay)
3 μM

溶解性

Solubility (25°C)* In vitro DMSO 100 mg/mL (182.27 mM)
Water <1 mg/mL (<1 mM)
Ethanol 35 mg/mL (63.79 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 18.23 mL 91.14 mL 182.28mL
0.5 mM 3.65 mL 18.23 mL 36.46 mL
1 mM 1.82 mL 9.11 mL 18.23 mL
5 mM 0.36 mL 1.82 mL 3.65 mL

*The above data is based on the productmolecular weight 548.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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