ICG-001

Name: ICG-001
SKU: A11039

目录号: A11039

Wnt/beta-catenin 抑制剂

Product Citations (5)

ICG-001 Chemical Structure

CAS NO. 780757-88-2

ICG-001是Wnt/β-catenin信号传导途径的特异性抑制剂，可抑制β-catenin/环状AMP响应元件结合（CREB）蛋白的转录（IC50 = 3 uM）。

库存：现货

规格	价格	数量
5 mg	￥ 600.00
10 mg	￥ 1,000.00
25 mg	￥ 2,400.00
100 mg	￥ 5,500.00
10mM * 1mL in DMSO	￥ 1,250.00

或

添加到收藏

产品仅用于科学研究，不针对患者销售，望谅解.

产品详情

生物活性

ICG-001是Wnt/β-catenin信号传导途径的特异性抑制剂，可抑制β-catenin/环状AMP响应元件结合（CREB）蛋白的转录（IC50 = 3 uM）。

靶点信息

CBP (Cell-free assay)
3 μM

溶解度 *

In vitro (25°C)	DMSO	99 mg/mL (180.45 mM)
	Water	Insoluble
	Ethanol	10 mg/mL
In vivo	2% DMSO+50% PEG 300+5% Tween 80+ddH2O	4 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	18.23 mL	91.14 mL	182.28 mL
0.5 mM	3.65 mL	18.23 mL	36.46 mL
1 mM	1.82 mL	9.11 mL	18.23 mL
5 mM	0.36 mL	1.82 mL	3.65 mL

*The above data is based on the productmolecular weight 548.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A11039
作用机制	Inhibitor (抑制剂)
M. Wt	548.6
Formula	C33H32N4O4
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	780757-88-2
Synonyms	ICG001
SMILES	C1CN([C@H]2CN(C(=O)[C@@H](N2C1=O)CC3=CC=C(C=C3)O)CC4=CC=CC5=CC=CC=C54)C(=O)NCC6=CC=CC=C6