Ichorcumab (JNJ-375) is a fully human monoclonal antibody of the IgG4 subclass, specifically designed to target thrombin. This antibody selectively binds to exosite 1 on thrombin, effectively inhibiting substrate binding while preserving the enzyme's catalytic activity. For experimental controls, the recommended isotype control is Human IgG4 (S228P) kappa.
Ichorcumab (JNJ-375) is a fully human monoclonal antibody of the IgG4 subclass, specifically designed to target thrombin. This antibody selectively binds to exosite 1 on thrombin, effectively inhibiting substrate binding while preserving the enzyme's catalytic activity. For experimental controls, the recommended isotype control is Human IgG4 (S228P) kappa.
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