IDH1 Inhibitor 1
目录号: A20065
IDH1 抑制剂
IDH1 Inhibitor 1 是一种强效的、可口服的、能穿透大脑的、选择性的突变 IDH1 抑制剂,其半抑制浓度(IC50)分别为 0.021 μM、0.045 μM 和 2.52 μM,针对 IDH1R132H、IDH1R132C 和 IDH1WT。具有抗癌活性。
Discription | IDH1 Inhibitor 1 is a potent, orally bioavailable, brain-penetrant and selective mutant IDH1 inhibitor with IC50s of 0.021 μM, 0.045 μM, and 2.52 μM for IDH1R132H, IDH1R132C, and IDH1WT, respectively. Anticancer activity. |
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目录号 | A20065 |
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分子式 | C20H18F4N6O2 |
分子量 | 450.39 |
CAS号 | 2234285-81-3 |
SMILES | C[C@H](NC1=NC(N2[C@@H](CF)COC2=O)=CC=N1)C(N=C3)=CN3C4=CC=C(C(F)(F)F)C=C4 |
储存条件 | Store lyophilized at -20ºC, keep desiccated. |
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2