Iluzanebart is a human monoclonal IgG1 antibody designed as an agonist for human Triggering Receptor Expressed on Myeloid cells 2 (hTREM2). This antibody enhances the survival and functionality of microglia by activating the TREM2 signaling pathway, thereby compensating for deficits in CSF1R (Colony Stimulating Factor 1 Receptor) function. It is specifically developed for use in research related to adult-onset leukoencephalopathy with CSF1R pathology (CSF1R-ALSP), providing a valuable tool for investigating the molecular mechanisms and potential therapeutic targets for this condition.
Iluzanebart is a human monoclonal IgG1 antibody designed as an agonist for human Triggering Receptor Expressed on Myeloid cells 2 (hTREM2). This antibody enhances the survival and functionality of microglia by activating the TREM2 signaling pathway, thereby compensating for deficits in CSF1R (Colony Stimulating Factor 1 Receptor) function. It is specifically developed for use in research related to adult-onset leukoencephalopathy with CSF1R pathology (CSF1R-ALSP), providing a valuable tool for investigating the molecular mechanisms and potential therapeutic targets for this condition.
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