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IMD 0354

促销

IKK 抑制剂

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产品目录号: A12837

库存状态:中国现货中国现货

产品名 目录号 价格 数量
IMD 0354 10mg A12837-10
¥ 800.00
IMD 0354 25mg A12837-25
¥ 1,500.00
IMD 0354 50mg A12837-50
¥ 2,100.00
IMD 0354 100mg A12837-100
¥ 3,500.00
IMD 0354 10mM * 1mL in DMSO A12837-10mM-D
¥ 720.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

IMD 0354 is an inhibitor of IκB kinase-β (IKKβ) that blocks NF-κB nuclear translocation.

IMD 0354

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顾客使用 Adooq 产品发表的高质量科研文献
Adooq 顾客使用 IMD 0354 发表的文献 (1)
  • Anton Lennikov, .et al. Selective IKK2 inhibitor IMD0354 disrupts NF-百B signaling to suppress corneal inflammation and angiogenesis, Angiogenesis, 2018, 21(2): 267每285 PMID: 29332242

Chemical Information

目录号 A12837
Mechanism of action Inhibitor
分子量 383.67
化学分子式 C15H8ClF6NO2
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 978-62-1
Synonyms IMD-0354, IMD0354
SMILES code C1=CC(=C(C=C1Cl)C(=O)NC2=CC(=CC(=C2)C(F)(F)F)C(F)(F)F)O
化学名称 N-[3,5-Bis(trifluoromethyl)phenyl]-?5-chloro-2-hydroxybenzamide

生物活性

Description
IMD 0354 is an inhibitor of IκB kinase-β (IKKβ) that blocks NF-κB nuclear translocation.
Targets
IKKβ

溶解性

Solubility (25°C) * In vitro DMSO 10 mg/mL (26.06 mM)
Water <1 mg/mL (<1 mM)
Ethanol 77 mg/mL (200.69 mM)
In vivo 0.5% CMC/0.25% Tween 80, pH 4 10 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 26.06 mL 130.32 mL 260.64mL
0.5 mM 5.21 mL 26.06 mL 52.13 mL
1 mM 2.61 mL 13.03 mL 26.06 mL
5 mM 0.52 mL 2.61 mL 5.21 mL

*The above data is based on the productmolecular weight 383.67. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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