INCB28060

INCB28060 Chemical Structure

CAS NO. 1029712-80-8

INCB28060, a novel inhibitor of c-MET kinase. INCB28060 exhibits picomolar enzymatic potency and is highly specific for c-MET with more than 10,000-fold selectivity over a large panel of human kinases. This inhibitor potently blocks c-MET phosphorylation and activation of its key downstream effectors in c-MET-dependent tumor cell lines.

库存: 现货

规格 价格 数量
5 mg
¥ 600.00
10 mg
¥ 900.00
25 mg
¥ 1,800.00
50 mg
¥ 2,500.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

详情

INCB28060, a novel inhibitor of c-MET kinase. INCB28060 exhibits picomolar enzymatic potency and is highly specific for c-MET with more than 10,000-fold selectivity over a large panel of human kinases. This inhibitor potently blocks c-MET phosphorylation and activation of its key downstream effectors in c-MET-dependent tumor cell lines.
Targets
c-Met (Cell-free assay)
0.13 nM
In vitro DMSO 2 mg/mL (4.84 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 24.25 mL 121.24 mL 242.48 mL
0.5 mM 4.85 mL 24.25 mL 48.5 mL
1 mM 2.42 mL 12.12 mL 24.25 mL
5 mM 0.48 mL 2.42 mL 4.85 mL

*The above data is based on the productmolecular weight 412.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Technical Details

目录号 A11132
MECHANISM OF ACTION Inhibitor
M. Wt 412.4
Formula C23H17FN6O
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1029712-80-8
Synonyms INCB-28060, INC-280, INC280
SMILES CNC(=O)C1=C(C=C(C=C1)C2=NN3C(=CN=C3N=C2)CC4=CC5=C(C=C4)N=CC=C5)F

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