Inclacumab is a recombinant human monoclonal IgG4 antibody that exhibits high selectivity for P-selectin, with a dissociation constant (Kd) of 9.9 nM. This antibody effectively inhibits the interaction between P-selectin and its ligand, P-selectin glycoprotein ligand 1 (PSGL-1), with a half-maximal inhibitory concentration (IC50) of 1.9 ??g/mL. It is particularly effective in blocking cell adhesion mediated by P-selectin, making it a valuable tool for research into inflammatory and cardiovascular diseases where P-selectin plays a key role.
Inclacumab is a recombinant human monoclonal IgG4 antibody that exhibits high selectivity for P-selectin, with a dissociation constant (Kd) of 9.9 nM. This antibody effectively inhibits the interaction between P-selectin and its ligand, P-selectin glycoprotein ligand 1 (PSGL-1), with a half-maximal inhibitory concentration (IC50) of 1.9 ??g/mL. It is particularly effective in blocking cell adhesion mediated by P-selectin, making it a valuable tool for research into inflammatory and cardiovascular diseases where P-selectin plays a key role.
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