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Iincyclinide, also known as CMT-3 and COL-3, is a MMP inhibitor and a chemically-modified tetracycline with potential antineoplastic activity. Incyclinide inhibits matrix metalloproteinases (MMPs), thereby inducing extracellular matrix degradation, and inhibiting angiogenesis, tumor growth and invasion, and metastasis. This agent also causes mitochondrial depolarization in tumor cells and induces both cellular apoptosis and tissue necrosis.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 26.93 mL | 134.65 mL | 269.29 mL |
| 0.5 mM | 5.39 mL | 26.93 mL | 53.86 mL |
| 1 mM | 2.69 mL | 13.46 mL | 26.93 mL |
| 5 mM | 0.54 mL | 2.69 mL | 5.39 mL |
*The above data is based on the productmolecular weight 371.34. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A17240 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 371.34 |
| Formula | C19H17NO7 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 15866-90-7 |
| Synonyms | CMT-3; CMT 3; CMT3; COL3; COL-3; COL 3 |
| SMILES | O=C(C1=C(O)C[C@@](C[C@@]2([H])C(C(C3=C(O)C=CC=C3C2)=O)=C4O)([H])[C@@]4(O)C1=O)N |
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