Indirubin

目录号: A10471

CDK & GSK-3β inhibitor

Indirubin

Indirubin Chemical Structure

CAS NO. 479-41-4

Indirubin, the active constituent of a Chinese antileukaemia medicine, is a potent cyclin-dependent kinases and GSK-3β inhibitor with IC50 of about 5 μM and 0.6 μM.

库存: 现货

规格 价格 数量
5 mg
¥ 400.00
25 mg
¥ 1,200.00
50 mg
¥ 2,000.00
100 mg
¥ 3,500.00
10mM * 1mL in DMSO
¥ 800.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

详情

Indirubin, the active constituent of a Chinese antileukaemia medicine, is a potent cyclin-dependent kinases and GSK-3β inhibitor with IC50 of about 5 μM and 0.6 μM.
Targets
Target Value
GSK-3βIC50: 0.6μM
CDK2/CyclinAIC50: 2.2μM
CDK5/p35IC50: 5.5μM
CDK1/CyclinBIC50: 10μM
C-RafIC50: >10μM
CDK4/CyclinD1IC50: 12μM
c-SrcIC50: 18μM
ERK2IC50: 43μM
ERK1IC50: >100μM
MAPKKIC50: >100μM
PKCαIC50: >100μM
PKCβ1IC50: >100μM
PKCβ2IC50: >100μM
PKCγIC50: >100μM
PKCδIC50: >100μM
PKCεIC50: >100μM
PKCηIC50: >100μM
PKCζIC50: >100μM
c-AblIC50: >1000μM
In vitro DMSO 53 mg/mL (202.08 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 38.12 mL 190.62 mL 381.24 mL
0.5 mM 7.62 mL 38.12 mL 76.25 mL
1 mM 3.81 mL 19.06 mL 38.12 mL
5 mM 0.76 mL 3.81 mL 7.62 mL

*The above data is based on the productmolecular weight 262.3 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Technical Details

目录号 A10471
MECHANISM OF ACTION Inhibitor
M. Wt 262.3
Formula C16H10N2O2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 479-41-4
Synonyms Couroupitine B, Indigo red
SMILES C1=CC=C2C(=C1)/C(=C\3/C(=O)C4=CC=CC=C4N3)/C(=O)N2

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