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Indomethacin (Indocid, Indocin)

促销

COX 抑制剂

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产品目录号: A10474

库存状态:中国现货中国现货

产品名 目录号 价格 数量
Indomethacin (Indocid, Indocin) 100mg A10474-100
¥ 500.00
Indomethacin (Indocid, Indocin) 250mg A10474-250
¥ 1,000.00
Indomethacin (Indocid, Indocin) 500mg A10474-500
¥ 1,800.00
Indomethacin (Indocid, Indocin) 1000mg A10474-1000
¥ 3,300.00
Indomethacin 10mM * 1mL in DMSO A10474-10mM-D
¥ 610.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

Indomethacin is a nonselective COX1 and COX2 inhibitor with IC50 of 0.1 μg/mL and 5 μg/mL, respectively. Indomethacin(Indocid, Indocin) is a non-steroidal anti-inflammatory compound commonly used to reduce fever, pain, stiffness, and swelling.

Indomethacin (Indocid, Indocin)

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顾客使用 Adooq 产品发表的高质量科研文献
Adooq 顾客使用 Indomethacin (Indocid, Indocin) 发表的文献 (2)
  • Azuma T, .et al. Distribution of six anticancer drugs and a variety of other pharmaceuticals, and their sorption onto sediments, in an urban Japanese river, Environ Sci Pollut Res Int, 2017, Aug;24(23):19021-19030 PMID: 28660504
  • Azuma T, .et al. Detection of pharmaceuticals and phytochemicals together with their metabolites in hospital effluents in Japan, and their contribution to sewage treatment plant influents, Sci Total Environ, 2016, Apr 1;548-549:189-197 PMID: 26802347

Chemical Information

目录号 A10474
Mechanism of action Inhibitor
分子量 357.79
化学分子式 C19H16ClNO4
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 53-86-1
Synonyms Indomethacin, Indochron E-R, Indocin-SR, Indocid, Indocin
SMILES code CC1=C(C2=C(N1C(=O)C3=CC=C(C=C3)Cl)C=CC(=C2)OC)CC(=O)O
化学名称 1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic acid

生物活性

Description
Indomethacin is a nonselective COX1 and COX2 inhibitor with IC50 of 0.1 μg/mL and 5 μg/mL, respectively. Indomethacin(Indocid, Indocin) is a non-steroidal anti-inflammatory compound commonly used to reduce fever, pain, stiffness, and swelling.
Targets
COX1 COX-2
0.28 μM14 μM

溶解性

Solubility (25°C)* In vitro DMSO 72 mg/mL (201.23 mM)
Water <1 mg/mL (<1 mM)
Ethanol 24 mg/mL (67.07 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 27.95 mL 139.75 mL 279.49mL
0.5 mM 5.59 mL 27.95 mL 55.9 mL
1 mM 2.79 mL 13.97 mL 27.95 mL
5 mM 0.56 mL 2.79 mL 5.59 mL

*The above data is based on the productmolecular weight 357.79. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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