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INK 128 (MLN0128)


mTOR 抑制剂

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产品目录号: A11461


产品名 目录号 价格 数量
INK 128 5mg A11461-5
¥ 800.00
INK 128 10mg A11461-10
¥ 1,000.00
INK 128 25mg A11461-25
¥ 1,800.00
INK 128 50mg A11461-50
¥ 2,500.00
INK 128 10mM * 1mL in DMSO A11461-10mM-D
¥ 800.00



INK 128 is a TORC1/2 inhibitor, is also an orally bioavailable inhibitor of raptor-mTOR (TOR complex 1 or TORC1) and rictor-mTOR (TOR complex 2 or TORC2) with potential antineoplastic activity.

INK 128 (MLN0128)




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Chemical Information

目录号 A11461
Mechanism of action Inhibitor
分子量 309.3
化学分子式 C15H15N7O
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 1224844-38-5
Synonyms INK128, INK-128
SMILES code CC(C)N1C2=C(C(=N1)C3=CC4=C(C=C3)OC(=N4)N)C(=NC=N2)N
化学名称 3-(2-Amino-5-benzoxazolyl)-1-(1-methylethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine


INK 128 is a TORC1/2 inhibitor, is also an orally bioavailable inhibitor of raptor-mTOR (TOR complex 1 or TORC1) and rictor-mTOR (TOR complex 2 or TORC2) with potential antineoplastic activity.
Target Value
mTORki: 1.4nM
mTORki: 1.4nM
PI3KαIC50: 219nM
PI3KγIC50: 221nM
PI3KδIC50: 230nM
PI3KβIC50: 5293nM


Solubility (25°C) * In vitro DMSO 62 mg/mL (200.43 mM)
Water <1 mg/mL (<1 mM)
Ethanol 2 mg/mL (6.46 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.


Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 32.33 mL 161.66 mL 323.31mL
0.5 mM 6.47 mL 32.33 mL 64.66 mL
1 mM 3.23 mL 16.17 mL 32.33 mL
5 mM 0.65 mL 3.23 mL 6.47 mL

*The above data is based on the productmolecular weight 309.3 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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