IOX 2

Name: IOX 2
SKU: A11924
Price: 175 CNY
Rating: 5 (1 reviews)

目录号: A11924

HIF-PHD 抑制剂

1 篇发表文献

IOX2 是一种强效的 HIF-1α 脯氨酸羟化酶-2（PHD2）抑制剂，其在无细胞试验中的 IC50 为 21 nM，对 JMJD2A、JMJD2C、JMJD2E、JMJD3 或 2OG 氧化酶 FIH 的选择性超过 100 倍。

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Grouped product items
规格	价格	库存
1mg	¥175.00	现货
2mg	¥280.00	现货
5mg	¥420.00	现货
10mg	¥560.00	现货
25mg	¥1,190.00	现货
50mg	¥2,205.00	现货
*10mM 1mL in DMSO**	¥560.00	现货
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重要通知：仅供研究使用。我们不向患者销售。

Data Sheet

SDS

顾客使用 Adooq 产品发表的高质量科研文献

Adooq用户使用IOX 2发表的1篇文献

Mun Chiang Chan, etc. Potent and Selective Triazole-Based Inhibitors of the Hypoxia-Inducible Factor Prolyl-Hydroxylases with Activity in the Murine Brain. PLoS One. 2015; 10(7): e0132004.

生物活性

Discription

IOX2 is a potent inhibitor of HIF-1α prolyl hydroxylase-2 (PHD2) with IC50 of 21 nM in a cell-free assay, >100-fold selectivity over JMJD2A, JMJD2C, JMJD2E, JMJD3, or the 2OG oxygenase FIH.

Targets

Target	Value

产品信息

目录号	A11924
分子式	C19H16N2O5
分子量	352.3
CAS号	931398-72-0
SMILES	C1=CC=C(C=C1)CN2C3=CC=CC=C3C(=C(C2=O)C(=O)NCC(=O)O)O
其他名称	IOX-2, IOX2
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

溶解性数据

In vitro (25°C)	DMSO	7 mg/mL (19.86 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	5% DMSO+30% PEG 300+ddH2O	1 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	28.38 mL	141.92 mL	283.85 mL
0.5 mM	5.68 mL	28.38 mL	56.77 mL
1 mM	2.84 mL	14.19 mL	28.38 mL
5 mM	0.57 mL	2.84 mL	5.68 mL

Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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* Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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