IOX 2 Chemical Structure

CAS NO. 931398-72-0

IOX2 is a potent inhibitor of HIF-1α prolyl hydroxylase-2 (PHD2) with IC50 of 21 nM in a cell-free assay, >100-fold selectivity over JMJD2A, JMJD2C, JMJD2E, JMJD3, or the 2OG oxygenase FIH.

库存: 现货

规格 价格 数量
10 mg
¥ 850.00
25 mg
¥ 1,800.00
50 mg
¥ 3,200.00
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IOX2 is a potent inhibitor of HIF-1α prolyl hydroxylase-2 (PHD2) with IC50 of 21 nM in a cell-free assay, >100-fold selectivity over JMJD2A, JMJD2C, JMJD2E, JMJD3, or the 2OG oxygenase FIH.
Targets
PHD2 (Cell-free assay)
21 nM
In vitro DMSO 7 mg/mL (19.86 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 28.38 mL 141.92 mL 283.85 mL
0.5 mM 5.68 mL 28.38 mL 56.77 mL
1 mM 2.84 mL 14.19 mL 28.38 mL
5 mM 0.57 mL 2.84 mL 5.68 mL

*The above data is based on the productmolecular weight 352.3 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A11924
MECHANISM OF ACTION Inhibitor
M. Wt 352.3
Formula C19H16N2O5
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 931398-72-0
Synonyms IOX-2, IOX2
SMILES C1=CC=C(C=C1)CN2C3=CC=CC=C3C(=C(C2=O)C(=O)NCC(=O)O)O

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