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2OG oxygenases 抑制剂

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产品目录号: A14277


产品名 目录号 价格 数量
IOX1 10mg A14277-10
¥ 900.00
IOX1 25mg A14277-25
¥ 2,000.00
IOX1 50mg A14277-50
¥ 3,550.00



IOX1 is a potent and broad-spectrum inhibitor of 2OG oxygenases, including the JmjC demethylases.





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Chemical Information

目录号 A14277
Mechanism of action Inhibitor
分子量 189.17
化学分子式 C10H7NO3
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 5852-78-8
Synonyms IOX 1, Iox-1
SMILES code C1=CC2=C(C=CC(=C2N=C1)O)C(=O)O
化学名称 8-hydroxy-5-Quinolinecarboxylic acid


IOX1 is a potent and broad-spectrum inhibitor of 2OG oxygenases, including the JmjC demethylases.
Target Value
KDM3AIC50: 0.1μM
KDM4CIC50: 0.6μM
KDM6BIC50: 1.6μM
KDM2AIC50: 1.8μM
KDM4EIC50: 2.3μM
KDM5CIC50: 19μM
PHD2IC50: 33μM


Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 52.86 mL 264.31 mL 528.63mL
0.5 mM 10.57 mL 52.86 mL 105.73 mL
1 mM 5.29 mL 26.43 mL 52.86 mL
5 mM 1.06 mL 5.29 mL 10.57 mL

*The above data is based on the productmolecular weight 189.17. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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