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Ipatasertib dihydrochloride (GDC-0068 dihydrochloride) is a highly selective pan-Akt inhibitor targeting Akt1/2/3 with IC50 of 5/18/8 nM, 620-fold selectivity over PKA.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 18.84 mL | 94.18 mL | 188.35 mL |
| 0.5 mM | 3.77 mL | 18.84 mL | 37.67 mL |
| 1 mM | 1.88 mL | 9.42 mL | 18.84 mL |
| 5 mM | 0.38 mL | 1.88 mL | 3.77 mL |
*The above data is based on the productmolecular weight 530.92. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A21734 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 530.92 |
| Formula | C24H34Cl3N5O2 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 1396257-94-5 |
| Synonyms | GDC-0068 (dihydrochloride), GDC0068, GDC0068; RG-7440 dihydrochloride, RG7440, RG 7440 |
| SMILES | ClC1=CC=C([C@@H](CNC(C)C)C(N2CCN(C3=C([C@H](C)C[C@H]4O)C4=NC=N3)CC2)=O)C=C1.[H]Cl.[H]Cl |
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