IPI-145 (Duvelisib, INK1197)

Name: IPI-145 (Duvelisib, INK1197)
SKU: A12422
Price: 245 CNY
Rating: 5 (288 reviews)

目录号: A12422

PI3K-δ/PI3K-γ 抑制剂

IPI-145，亦称为 INK-1197，是一种口服生物利用度高、选择性强且效力高的小分子抑制剂，针对磷脂酰肌醇-3激酶（PI3K）的 delta 和 gamma 亚型，具有潜在的免疫调节和抗肿瘤活性。

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Grouped product items
规格	价格	库存
2mg	¥245.00	现货
5mg	¥385.00	现货
10mg	¥560.00	现货
25mg	¥875.00	现货
50mg	¥1,050.00	现货
100mg	¥1,750.00	现货
*10mM 1mL in DMSO**	¥595.00	现货
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Data Sheet

SDS

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生物活性

Discription

IPI-145, also known as INK-1197, is an orally bioavailable, highly selective and potent small molecule inhibitor of the delta and gamma isoforms of phosphoinositide-3 kinase (PI3K) with potential immunomodulating and antineoplastic activities.

Targets

Target	Value

Cell Research

Cell Line	Type	Value	Description	References

产品信息

目录号	A12422
分子式	C22H17ClN6O
分子量	416.86
CAS号	1201438-56-3
SMILES	C[C@@H](C1=CC2=C(C(=CC=C2)Cl)C(=O)N1C3=CC=CC=C3)NC4=NC=NC5=C4NC=N5
其他名称	IPI145; IPI 145; IPI-145. INK-1197; INK 1197; INK1197
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

溶解性数据

In vitro (25°C)	DMSO	76 mg/mL (182.31 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	30% PEG400+0.5% Tween80+5% propylene glycol	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	23.99 mL	119.94 mL	239.89 mL
0.5 mM	4.8 mL	23.99 mL	47.98 mL
1 mM	2.4 mL	11.99 mL	23.99 mL
5 mM	0.48 mL	2.4 mL	4.8 mL

Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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* Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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