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IRAK-IN-6，也称为IRAK抑制剂6，是白介素1受体相关激酶4（IRAK-4）抑制剂。 据报道，IRAK-4对于激活包括NF-kB和MAPK途径在内的细胞内信号级联反应至关重要，这对于炎症细胞因子的产生至关重要。
| In vitro | DMSO | 6 mg/mL (15.13 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 25.22 mL | 126.12 mL | 252.23 mL |
| 0.5 mM | 5.04 mL | 25.22 mL | 50.45 mL |
| 1 mM | 2.52 mL | 12.61 mL | 25.22 mL |
| 5 mM | 0.5 mL | 2.52 mL | 5.04 mL |
*The above data is based on the productmolecular weight 396.46. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A11460 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 396.46 |
| Formula | C20H20N4O3S? |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 1042672-97-8 |
| Synonyms | IRAK-IN-6, IRAK IN 6, IRAKIN6, IRAK inhibitor 6 |
| SMILES | O=C(C1=CSC(C2=CC=CN=C2)=N1)NC3=CC=C(N4CCOCC4)C=C3OC |
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