Isatuximab is a monoclonal antibody designed to specifically target CD38, a transmembrane receptor and ectoenzyme prominently expressed on the surface of cells in hematological malignancies, particularly multiple myeloma (MM). This antibody exerts its antitumor effects through a variety of biological pathways, including antibody-dependent cellular-mediated cytotoxicity (ADCC), complement-dependent cytotoxicity (CDC), antibody-dependent cellular phagocytosis (ADCP), and the direct induction of apoptosis independently of crosslinking. Additionally, Isatuximab directly inhibits the enzymatic activity of CD38, which plays a crucial role in numerous cellular processes. This multifaceted mechanism of action makes Isatuximab a valuable tool in the research and treatment of multiple myeloma and other CD38-related disorders.
Isatuximab is a monoclonal antibody designed to specifically target CD38, a transmembrane receptor and ectoenzyme prominently expressed on the surface of cells in hematological malignancies, particularly multiple myeloma (MM). This antibody exerts its antitumor effects through a variety of biological pathways, including antibody-dependent cellular-mediated cytotoxicity (ADCC), complement-dependent cytotoxicity (CDC), antibody-dependent cellular phagocytosis (ADCP), and the direct induction of apoptosis independently of crosslinking. Additionally, Isatuximab directly inhibits the enzymatic activity of CD38, which plays a crucial role in numerous cellular processes. This multifaceted mechanism of action makes Isatuximab a valuable tool in the research and treatment of multiple myeloma and other CD38-related disorders.
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