Iscalimab (CFZ-533) is a non-depleting IgG1 monoclonal antibody that selectively targets CD40 with a dissociation constant (K_D) of 0.3 nM. This high-affinity interaction underscores its utility in the study of immunological disorders, including Graves' hyperthyroidism and various autoimmune diseases. Iscalimab is engineered to modulate the CD40-CD40L pathway, pivotal in immune regulation, without causing depletion of immune cells, making it an ideal tool for advanced immunological research and therapeutic investigations.
Iscalimab (CFZ-533) is a non-depleting IgG1 monoclonal antibody that selectively targets CD40 with a dissociation constant (K_D) of 0.3 nM. This high-affinity interaction underscores its utility in the study of immunological disorders, including Graves' hyperthyroidism and various autoimmune diseases. Iscalimab is engineered to modulate the CD40-CD40L pathway, pivotal in immune regulation, without causing depletion of immune cells, making it an ideal tool for advanced immunological research and therapeutic investigations.
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