Isecarosmab (M-6495) is a monoclonal antibody targeting ADAMTS with a dissociation constant (K_D) of 3.65 pM, indicative of high affinity binding. This antibody exhibits chondroprotective and anti-inflammatory properties, making it valuable in research focused on inflammatory and degenerative joint diseases. Additionally, Isecarosmab has been engineered to bind albumin, which enhances its plasma half-life, thereby potentially improving its therapeutic efficacy and stability in physiological conditions.
Isecarosmab (M-6495) is a monoclonal antibody targeting ADAMTS with a dissociation constant (K_D) of 3.65 pM, indicative of high affinity binding. This antibody exhibits chondroprotective and anti-inflammatory properties, making it valuable in research focused on inflammatory and degenerative joint diseases. Additionally, Isecarosmab has been engineered to bind albumin, which enhances its plasma half-life, thereby potentially improving its therapeutic efficacy and stability in physiological conditions.
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