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Istradefylline (KW-6002)


A2A 拮抗剂

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产品目录号: A11451


产品名 目录号 价格 数量
Istradefylline 5mg A11451-5
¥ 700.00
Istradefylline 10mg A11451-10
¥ 1,200.00
Istradefylline 25mg A11451-25
¥ 2,400.00
Istradefylline 50mg A11451-50
¥ 3,800.00



Istradefylline (KW-6002) is a selective antagonist at the A2A receptor. It has been found to be useful in the treatment of Parkinson's disease.

Istradefylline (KW-6002)




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Chemical Information

目录号 A11451
Mechanism of action Antagonist
分子量 384.4
化学分子式 C20H24N4O4
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 155270-99-8
Synonyms KW-6002,KW6002
SMILES code CCN1C2=C(C(=O)N(C1=O)CC)N(C(=N2)/C=C/C3=CC(=C(C=C3)OC)OC)C
化学名称 8-[(E)-2-(3,4-dimethoxyphenyl)vinyl]-1,3-diethyl-7-methyl-3,7-dihydro-1H-purine-2,6-dione


Istradefylline (KW-6002) is a selective antagonist at the A2A receptor. It has been found to be useful in the treatment of Parkinson's disease.
Adenosine A2A receptor
2.2 nM(Ki)


Solubility (25°C) * In vitro DMSO 6 mg/mL (15.6 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% propylene glycol, 5% Tween 80, 65% D5W 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.


Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 26.01 mL 130.07 mL 260.15mL
0.5 mM 5.2 mL 26.01 mL 52.03 mL
1 mM 2.6 mL 13.01 mL 26.01 mL
5 mM 0.52 mL 2.6 mL 5.2 mL

*The above data is based on the productmolecular weight 384.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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