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IWP-2是Porcn功能的灭活剂和Wnt生成的抑制剂，无细胞试验中IC50为27 nM,并阻止β-catenin的积累。Wnt/b-catenin途径维持使干细胞保持多能性的转录程序。
靶点信息
| Wnt (Cell-free assay) | ||||
| 27 nM |
| In vitro | DMSO | Insoluble | |
| Water | Insoluble | ||
| Ethanol | DMF: 48 mg/mL (102.87 mM) | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 21.43 mL | 107.16 mL | 214.32 mL |
| 0.5 mM | 4.29 mL | 21.43 mL | 42.86 mL |
| 1 mM | 2.14 mL | 10.72 mL | 21.43 mL |
| 5 mM | 0.43 mL | 2.14 mL | 4.29 mL |
*The above data is based on the productmolecular weight 466.6. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A12707 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 466.6 |
| Formula | C22H18N4O2S3 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 686770-61-6 |
| Synonyms | IWP 2,IWP2 |
| SMILES | CC1=CC2=C(C=C1)N=C(S2)NC(=O)CSC3=NC4=C(C(=O)N3C5=CC=CC=C5)SCC4 |
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