IWP-3

目录号: A13192

Wnt inhibitor

IWP-3

IWP-3 Chemical Structure

CAS NO. 687561-60-0

IWP-3 is an inhibitor of Wnt production. Blocks Wnt pathway activity in vitro ( IC₅₀ = 40 nM). IWP-3 inactivates Porcupine (Porcn), a membrane-bound O-acyltransferase responsible for palmitoylating Wnt proteins, which is essential for their signaling ability and secretion. Through blockade of Wnt signaling, IWP-3 has been used to promote cardiomyocyte generation from human embryonic stem cells (EC₅₀ = 1.2 μM).

库存: 现货

规格 价格 数量
5 mg
¥ 980.00
10 mg
¥ 1,800.00
25 mg
¥ 3,900.00
100 mg
¥ 11,000.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

生物活性

IWP-3 is an inhibitor of Wnt production. Blocks Wnt pathway activity in vitro ( IC₅₀ = 40 nM). IWP-3 inactivates Porcupine (Porcn), a membrane-bound O-acyltransferase responsible for palmitoylating Wnt proteins, which is essential for their signaling ability and secretion. Through blockade of Wnt signaling, IWP-3 has been used to promote cardiomyocyte generation from human embryonic stem cells (EC₅₀ = 1.2 μM).
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 20.64 mL 103.18 mL 206.36 mL
0.5 mM 4.13 mL 20.64 mL 41.27 mL
1 mM 2.06 mL 10.32 mL 20.64 mL
5 mM 0.41 mL 2.06 mL 4.13 mL

*The above data is based on the productmolecular weight 484.59. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

产品技术资料

目录号 A13192
MECHANISM OF ACTION Inhibitor
M. Wt 484.59
Formula C22H17FN4O2S3
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 687561-60-0
Synonyms IWP 3,IWP3
SMILES O=C(CSC(N1C2=CC=C(F)C=C2)=NC3=C(SCC3)C1=O)NC4=NC5=C(C=C(C)C=C5)S4

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