Izeltabart is a humanized antibody with high affinity for ADAM9, designed for use in antibody-drug conjugate (ADC) applications. This antibody facilitates the site-specific attachment of Maytansinoid-based DM21-C, a drug-linker conjugate, to create the ADC known as IMGC936. The DM21-C component consists of a Maytansinoid, which acts as a microtubule inhibitor, linked via a stable tripeptide. IMGC936 demonstrates pronounced cytotoxic effects on ADAM9-expressing human tumor cell lines and has shown significant antitumor efficacy in xenograft tumor models. This product is pivotal for research focused on targeted cancer therapies, particularly those exploring the therapeutic potential of ADCs in oncology.
Izeltabart is a humanized antibody with high affinity for ADAM9, designed for use in antibody-drug conjugate (ADC) applications. This antibody facilitates the site-specific attachment of Maytansinoid-based DM21-C, a drug-linker conjugate, to create the ADC known as IMGC936. The DM21-C component consists of a Maytansinoid, which acts as a microtubule inhibitor, linked via a stable tripeptide. IMGC936 demonstrates pronounced cytotoxic effects on ADAM9-expressing human tumor cell lines and has shown significant antitumor efficacy in xenograft tumor models. This product is pivotal for research focused on targeted cancer therapies, particularly those exploring the therapeutic potential of ADCs in oncology.
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